Product/Type/Warnings Potential problems from human ingestion of residue or metabolites jaundice, hepatic cholestasis and acute cytolytic hepatitis have been reported.
Hemic and Lymphatic Systems: Anemia, including hemolytic anemia, thrombocytopenia, thrombocytopenic purpura, eosinophilia, leukopenia, and agranulocytosis have been reported during therapy with penicillins.
These reactions are usually reversible on discontinuation of therapy and are believed to be hypersensitivity phenomena.
Central Nervous System: Reversible hyperactivity, agitation, anxiety, insomnia, confusion, convulsions, behavioral changes, and/or dizziness have been reported rarely.
Miscellaneous: Tooth discoloration (brown, yellow, or gray staining) has been rarely reported.
Most reports occurred in pediatric patients.
Discoloration was reduced or eliminated with brushing or dental cleaning in most cases.
Http://www.drugs.com/sfx/amoxicillin-side-effects.html 8. Ampicillin sodium Antibiotic for treatment of respiratory tract infections (pneumonia and strangles) and skin and soft tissue infections (abscesses and wounds), when caused by susceptible organisms. 21 CFR § 522.90c – “Do not use in horses intended for human consumption.” COMMON SIDE EFFECTS Inflammation and redness of the tongue; irritation of mouth or throat; mild diarrhea; nausea; second infection; vomiting.
SEVERE SIDE EFFECTS Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bloody stools; severe diarrhea; stomach pain/cramps; vaginal irritation or discharge.
Http://www.drugs.com/sfx/ampicillin-side-effects.html See also side effects for ampicillin injection: •upset stomach, diarrhea, vomiting, mild skin rash More severe: •severe skin rash, itching, hives, difficulty breathing or swallowing, wheezing, unusual bleeding or bruising, headache, dizziness, seizures, sore mouth or throat http://www.nlm.nih.gov/medlineplus/druginfo/meds/a601133.html Material Safety Data Sheet (“MSDS”) for ampicillin sodium salt: Toxic Effects on Humans: Hazardous in case of ingestion, of inhalation.
Http://www.sciencelab.com/msds.php?msdsId=9925610 9. Aspirin Aspir-paste http://www.drsfostersmith.com/1/1/1 0913-aspir-paste-by-oral-x.html Reduces joint, muscle, and lameness pain. WARNINGS/PRECAUTIONS Avoid in children or teenagers for chickenpox or flu symptoms; Reye’s syndrome may occur.
May cause severe allergic reaction (hives, facial swelling, asthma, shock) and stomach bleeding.
Avoid in asthma, stomach problems that persist or recur, ulcers, or bleeding problems.
ADVERSE REACTIONS Allergic reaction, hives, facial swelling, asthma, shock.
Http://www.pdr.net/drugpages/concisemonograph.aspx?concise=195 3 Drug Product/Type/Warnings Potential problems from human ingestion of residue or metabolites Can cause excessive bleeding in those taking warfarin; http://stroke.ahajournals.org/content/40/5/1944.full Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); black or bloody stools; confusion; diarrhea; dizziness; drowsiness; hearing loss; ringing in the ears; severe or persistent stomach pain; unusual bruising; vomiting.
Http://www.drugs.com/sfx/aspirin-side-effects.html 10. Avermectin A1a, 5-Odemethyl-25-de(1methylpropyl)-22,23dihydro-25-(1methylethyl)- Farnam Ivercare (dewormer) http://msds.farnam.com/m001116.ht m Ivercare Paste is labeled “Do not use in horses intended for food purposes.” http://www.drugs.com/vet/ivercarepaste-1-87.html Equipoise Equipoise Injectable http://www.drugs.com/vet/equipoiseinjectable-can.html A hazardous component of the Farnam Ivercare dewormer product.
Http://msds.farnam.com/m001116.htm Links to the toxicological literature here: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=14145#x50 http://toxnet.nlm.nih.gov/cgi-bin/sis/search/r?dbs+toxline:@term+@rn+65195-519+@OR+@all 11. Benzyl alcohol ADVERSE REACTIONS Pruritis, erythema, pyoderma, ocular irritation.
Http://www.pdr.net/search/searchResult.aspx?searchCriteria=Benzyl+alcohol — Butorphanol For the relief of pain associated with colic and postpartum pain in adult horses and yearlings. 4 Drug Product/Type/Warnings 21 CFR § 522.246 – “Do not use in horses intended for human consumption.” Potential problems from human ingestion of residue or metabolites SEVERE SIDE EFFECTS Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blurred vision; burning, numbness, or tingling; change in the amount of urine produced; chest pain; confusion; ear pain; fainting; fast, slow, or irregular heartbeat; flushing; hallucinations; mental or mood changes (agitation, anxiety, depression); restlessness; ringing in the ears; seizures; severe or persistent dizziness, drowsiness, or light-headedness; severe or persistent headache or trouble sleeping; shortness of breath; slow, shallow, or difficult breathing; tremors; unusual swelling.
Http://www.drugs.com/sfx/butorphanol-side-effects.html In 2002, a woman in Oklahoma was hospitalized after using Pyranha fly spray on horses.
Her face was distorted, and her words slurred.
She reportedly had leg problems, tremors, memory problems.
The medical toxicologist’s conclusion was that the patient, a professional horse trainer, developed a complex neurotoxic movement disorder following sensitization to a product that contained 33% /butoxypolypropylene glycol/ BPG.
Adverse reactions and side effects of ingestion are unknown. 14. Butoxy Polypropylene Glycol Farnam Bronco Gold (fly spray) http://msds.farnam.com/m001650.ht m Farnam Endure Fly Spray http://msds.farnam.com/m000080.ht m Farnam Endure Sweat-Resistant http://msds.farnam.com/m001046.ht m Farnam Tri-Tec 14 http://msds.farnam.com/m000490.ht m Farnam Wipe (fly control 15. Carbadox Antibiotic used for growth promotion purposes (generic) Not permitted for use in food-producing animals in Australia (http://www.apvma.gov.au/registration/not_permitted.php) Or in Canada, or the European Union. (http://www.hc-sc.gc.ca/dhpmps/vet/faq/faq_mrl-lmr-eng.php#a6) Not for human use.
Http://www.drugs.com/pro/mecadox.html Chronic health effects, including cancer, mutagenic effect, changes in lung function.
Accidental ingestion may cause serious harm or be fatal.
MSDS SUPPLIER http://datasheets.scbt.com/sc-204668.pdf — Phenol is considered to be quite toxic to humans via oral exposure.
Anorexia, progressive weight loss, diarrhea, vertigo, salivation, a dark coloration of the urine, and blood and liver effects have been reported in chronically (long-term) exposed humans.
Animal studies have reported reduced fetal body weights, growth retardation, and abnormal development in the offspring of animals exposed to phenol by the oral route.
Http://www.epa.gov/ttn/atw/hlthef/phenol.html Serious and fatal adverse effects have been reported from ingestion of Phenylbutazone, including bone marrow suppression and aplastic anemia.
Banned in America for human use.
Nicholas Dodman, Nicolas Blondell, Ann M.
Marini, “Association of phenylbutazone usage with horses bought for slaughter: A public health risk”, FOOD AND CHEMICAL TOXICOLOGY 48 (2010) 1270–74. “Phenylbutazone is known to induce blood dyscrasias, including aplastic anemia, leukopenia, agranulocytosis, thrombocytopenia and deaths.
Hypersensitivity reactions of the serum-sickness type have also been reported.
In addition, phenylbutazone is a carcinogen, as determined by the National Toxicology Program.” 84. Phenylbutazone NSAID: Butazone 400 Butazone 1000 Butazone Concentrate Bute paste Butequine 21 USC §520.1770a – Tablets and boluses – Dogs and horses – “Do not use in horses intended for human consumption..” 21 USC § 522.1720 http://www.fda.gov/AnimalVeterinary/NewsEvents/CVMUpdates/ucm12407 8.htm Phenylbutazone is especially problematic for patients with a history of asthma attacks, hives, or other allergic reactions to aspirin or other NSAIDs.
It also should be avoided by patients with peptic ulcer disease or poor kidney function, since this medication 22 Drug Product/Type/Warnings – Injection – Dogs and horses – “Not for use in animals intended for food.” http://horsebackmagazine.com/hb/arc hives/13184 http://www.farmvet.com/pc-1500163-bute-paste-12-gm.aspx http://www.drugs.com/vet/butequinecan.html http://tuesdayshorse.wordpress.com/t ag/cfia/ Potential problems from human ingestion of residue or metabolites can aggravate both conditions.
Phenylbutazone is generally used with caution in patients taking blood thinning medications (anticoagulants), such as warfarin (Coumadin), because of an increased risk of bleeding.
Patients taking lithium can develop toxic blood lithium levels.
Additionally, patients taking cyclosporine (Sandimmune) can develop kidney toxicity. 85. Piperonyl Butoxide Repel-XP Fly control Do not use on horses intended for human consumption.
Http://www.drugs.com/vet/repel-xpemulsifiable-fly-spray.html Potential dangers to humans are unknown: “Data are not available from accidental poisonings, occupational exposures, or epidemiological studies regarding the reproductive and developmental toxicity of piperonyl butoxide.” npic.orst.edu/factsheets/pbotech.pdf Ingestion can cause vomiting and diarrhea.
Pesticide Action Network North America.
Piperonyl Butoxide, http://www.pesticideinfo.org/Detail_Chemical.jsp?Rec_Id=PC33240 The EPA classifies piperonyl butoxide as a group C carcinogen, a possible human carcinogen.
Environmental Protection Agency.
Reregistration Eligibility Decision for Piperonyl Butoxide. (June 2006).
Http://www.epa.gov/opp00001/reregistration/REDs/piperonyl_red.pdf 86. Polysulfated Glycosaminoglycan — Product/Type/Warnings for food.” “Not for use in horses intended for food.” http://www.drugs.com/vet/marquis15-w-w-ponazuril-antiprotozoal-oralpaste.html Potential problems from human ingestion of residue or metabolites 141-188 (Marquis), www.fda.gov/downloads/AnimalVeterinary/…/ucm117581.pdf 88. Prallethrin Insecticide Mosquito Halt Fly spray http://www.drugs.com/vet/mosquitohalt-repellent-spray-for-horses.html Potential poisoning, headache, dizziness, nausea, and seizure.
Http://www.pesticideinfo.org/Detail_Chemical.jsp?Rec_Id=PC35755 “Pyrethroid ingestion gives rise within minutes to a sore throat, nausea, vomiting and abdominal pain.
There may be mouth ulceration, increased secretions and/or dysphagia.
Systemic effects occur 4-48 hours after exposure.
Dizziness, headache and fatigue are common, and palpitations, chest tightness and blurred vision less frequent.coma and convulsions are the principal life-threatening features.
Most patients recover within 6 days. . . .” S.M.
Bradberry et al., Poisoning Due to Pyrethroids, Toxicol Rev. 24(2):93-106 (2005) (quoting abstract).
Available by prescription only and to be taken only under the monitoring of a physician.
Contraindicated for people with pre-exiting conditions involving the liver, kidney, or heart.
Praziquantel may cause side effects including headache, dizziness, stomach pain, nausea, fever, itching, hives (especially serious).
Http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0000474/ http://www.rxlist.com/biltricide-drug/patient-images-side-effects.htm 89. Praziquantel Dewormer For horses and humans Equimax Quest Plus Zimecterin Gold http://www.equimaxhorse.com/ http://www.drugs.com/vet/questplus-equine-oral-gel.html “Not for use in humans.” (Zimecterin) http://www.zimecterin.com/Zimecter inGold/index.html?=50 90. Prednisone Human and horse steroid 21 USC § 522.1890 – Horses, dogs and cats – “Not for use in horses intended for human consumption.” Steroids should be taken under a doctor’s supervision and have multiple significant adverse affects including severe allergic reactions, hormonal changes, changes in menstrual functions, mental and mood changes, respiratory problems, nausea and vomiting, joint swelling, vision changes, and unusual weight gain.
Can cause unknown and unwanted hormonal effects, including termination of pregnancy, to individuals who ingest without knowing.
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